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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P62834




USC-OGP 2-DE database:  P62834


P62834


General information about the entry
View entry in simple text format
Entry nameRAP1A_HUMAN
Primary accession numberP62834
Secondary accession number(s) P10113
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Ras-related protein Rap-1A; AltName: Full=C21KG; AltName: Full=G-22K; AltName: Full=GTP-binding protein smg p21A; AltName: Full=Ras-related protein Krev-1; Flags: Precursor;.
Gene nameName=RAP1A
Synonyms=KREV1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.41; Mw=22087
pI=5.34; Mw=20990



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.16; Mw=18906

Cross-references
UniProtKB/Swiss-ProtP62834; RAP1A_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameRAP1A_HUMAN
Primary accession numberP62834
Secondary accession number(s) P10113
Sequence was last modified on August 16, 2004 (version 1)
Annotations were last modified on March 15, 2017 (version 151)
Name and origin of the protein
DescriptionRecName: Full=Ras-related protein Rap-1A; AltName: Full=C21KG; AltName: Full=G-22K; AltName: Full=GTP-binding protein smg p21A; AltName: Full=Ras-related protein Krev-1; Flags: Precursor;
Gene nameName=RAP1A
Synonyms=KREV1
Encoded onName=RAP1A; Synonyms=KREV1
Keywords3D-structure; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Neurogenesis; Nucleotide-binding; Prenylation; Reference proteome; Tumor suppressor.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX12533; CAA31051.1; -; mRNA
EMBLM22995; AAA36150.1; -; mRNA
EMBLAF493912; AAM12626.1; -; mRNA
EMBLAL049557; CAB55685.2; ALT_SEQ; Genomic_DNA
EMBLBC014086; AAH14086.1; -; mRNA
CCDSCCDS840.1; -; .
PIRA32342; A32342; .
RefSeqNP_001010935.1; NM_001010935.2; .
RefSeqNP_001278825.1; NM_001291896.1; .
RefSeqNP_002875.1; NM_002884.3; .
RefSeqXP_016857451.1; XM_017001962.1; .
RefSeqXP_016857452.1; XM_017001963.1; .
RefSeqXP_016857453.1; XM_017001964.1; .
UniGeneHs.190334; -; .
UniGeneHs.586618; -; .
PDB1C1Y; X-ray; 1.90 A; A=1-167
PDB1GUA; X-ray; 2.00 A; A=1-167
PDB3KUC; X-ray; 1.92 A; A=1-167
PDB4KVG; X-ray; 1.65 A; A/C=1-167
PDBsum1C1Y; -; .
PDBsum1GUA; -; .
PDBsum3KUC; -; .
PDBsum4KVG; -; .
ProteinModelPortalP62834; -; .
SMRP62834; -; .
BioGrid111841; 71; .
DIPDIP-29106N; -; .
IntActP62834; 23; .
MINTMINT-1509313; -; .
STRING9606.ENSP00000348786; -; .
BindingDBP62834; -; .
ChEMBLCHEMBL1255139; -; .
iPTMnetP62834; -; .
PhosphoSitePlusP62834; -; .
SwissPalmP62834; -; .
BioMutaRAP1A; -; .
DMDM51338607; -; .
OGPP62834; -; .
EPDP62834; -; .
MaxQBP62834; -; .
PaxDbP62834; -; .
PeptideAtlasP62834; -; .
PRIDEP62834; -; .
TopDownProteomicsP62834; -; .
DNASU5906; -; .
EnsemblENST00000356415; ENSP00000348786; ENSG00000116473; .
EnsemblENST00000369709; ENSP00000358723; ENSG00000116473; .
GeneID5906; -; .
KEGGhsa:5906; -; .
UCSCuc001ebi.4; human; .
CTD5906; -; .
DisGeNET5906; -; .
GeneCardsRAP1A; -; .
HGNCHGNC:9855; RAP1A; .
MalaCardsRAP1A; -; .
MIM179520; gene; .
neXtProtNX_P62834; -; .
OpenTargetsENSG00000116473; -; .
PharmGKBPA34217; -; .
eggNOGKOG0395; Eukaryota; .
eggNOGCOG1100; LUCA; .
GeneTreeENSGT00860000133678; -; .
HOGENOMHOG000233973; -; .
HOVERGENHBG009351; -; .
InParanoidP62834; -; .
KOK04353; -; .
OMAARSFNSA; -; .
OrthoDBEOG091G0OOG; -; .
PhylomeDBP62834; -; .
TreeFamTF313014; -; .
ReactomeR-HSA-170968; Frs2-mediated activation; .
ReactomeR-HSA-170984; ARMS-mediated activation; .
ReactomeR-HSA-354192; Integrin alphaIIb beta3 signaling; .
ReactomeR-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; .
ReactomeR-HSA-372708; p130Cas linkage to MAPK signaling for integrins; .
ReactomeR-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; .
ReactomeR-HSA-392517; Rap1 signalling; .
ReactomeR-HSA-5674135; MAP2K and MAPK activation; .
ReactomeR-HSA-6798695; Neutrophil degranulation; .
ReactomeR-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; .
ReactomeR-HSA-6802948; Signaling by high-kinase activity BRAF mutants; .
ReactomeR-HSA-6802949; Signaling by RAS mutants; .
ReactomeR-HSA-6802952; Signaling by BRAF and RAF fusions; .
ReactomeR-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; .
ReactomeR-HSA-8875555; MET activates RAP1 and RAC1; .
SignaLinkP62834; -; .
SIGNORP62834; -; .
ChiTaRSRAP1A; human; .
EvolutionaryTraceP62834; -; .
GeneWikiRAP1A; -; .
GenomeRNAi5906; -; .
PROPR:P62834; -; .
ProteomesUP000005640; Chromosome 1; .
BgeeENSG00000116473; -; .
CleanExHS_RAP1A; -; .
ExpressionAtlasP62834; baseline and differential; .
GenevisibleP62834; HS; .
GOGO:0030054; C:cell junction; ISS:UniProtKB; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005769; C:early endosome; ISS:UniProtKB; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:Ensembl; .
GOGO:0005770; C:late endosome; ISS:UniProtKB; .
GOGO:0043209; C:myelin sheath; IEA:Ensembl; .
GOGO:0043005; C:neuron projection; IEA:Ensembl; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; .
GOGO:0045335; C:phagocytic vesicle; IEA:Ensembl; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0035579; C:specific granule membrane; TAS:Reactome; .
GOGO:0005525; F:GTP binding; IEA:UniProtKB-KW; .
GOGO:0003924; F:GTPase activity; TAS:ProtInc; .
GOGO:0032403; F:protein complex binding; IDA:UniProtKB; .
GOGO:0008565; F:protein transporter activity; IDA:UniProtKB; .
GOGO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB; .
GOGO:0000186; P:activation of MAPKK activity; TAS:Reactome; .
GOGO:0071320; P:cellular response to cAMP; IDA:UniProtKB; .
GOGO:0035690; P:cellular response to drug; IEA:Ensembl; .
GOGO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl; .
GOGO:1990090; P:cellular response to nerve growth factor stimulus; ISS:UniProtKB; .
GOGO:0061028; P:establishment of endothelial barrier; IMP:UniProtKB; .
GOGO:0097421; P:liver regeneration; IEA:Ensembl; .
GOGO:0032966; P:negative regulation of collagen biosynthetic process; IEA:Ensembl; .
GOGO:2000301; P:negative regulation of synaptic vesicle exocytosis; IEA:Ensembl; .
GOGO:0038180; P:nerve growth factor signaling pathway; ISS:UniProtKB; .
GOGO:0043312; P:neutrophil degranulation; TAS:Reactome; .
GOGO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB; .
GOGO:1905451; P:positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; IEA:Ensembl; .
GOGO:0046326; P:positive regulation of glucose import; IEA:Ensembl; .
GOGO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB; .
GOGO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB; .
GOGO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB; .
GOGO:2001214; P:positive regulation of vasculogenesis; ISS:UniProtKB; .
GOGO:0015031; P:protein transport; IDA:UniProtKB; .
GOGO:0032486; P:Rap protein signal transduction; IMP:UniProtKB; .
GOGO:1901888; P:regulation of cell junction assembly; IMP:UniProtKB; .
GOGO:0050796; P:regulation of insulin secretion; TAS:Reactome; .
GOGO:0097327; P:response to antineoplastic agent; IEA:Ensembl; .
GOGO:0007165; P:signal transduction; TAS:ProtInc; .
Gene3D3.40.50.300; -; 1; .
InterProIPR027417; P-loop_NTPase; .
InterProIPR005225; Small_GTP-bd_dom; .
InterProIPR001806; Small_GTPase; .
InterProIPR020849; Small_GTPase_Ras; .
PANTHERPTHR24070; PTHR24070; 1; .
PfamPF00071; Ras; 1; .
SUPFAMSSF52540; SSF52540; 1; .
TIGRFAMsTIGR00231; small_GTP; 1; .
PROSITEPS51421; RAS; 1; .



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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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